Our key articles on Alzheimer's disease and diabetes
Publications (full list)
  1. Arnold SE, Arvanitakis Z, Macauley-Rambach SL, Koenig AM, Wang HY, Ahima RS, Craft S, Gandy S, Buettner C, Stoecke LEl, Holtzman DM, and Nathan DM.  Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums.  Nat Rev Neurol. 2018.
     

  2. Ju YS, Ooms SJ, Sutphen C, Macauley SL, Zangrilli MA, Jerome G, Fagan AM, Mignot E, Zempel JM, Claassen JAHR, Holtzman DM.  Slow wave sleep disruption increased cerebrospinal fluid amyloid-beta.  Brain.  2017.
     

  3. Shyng C, Macauley SL, Dearborn JT, Sands MS. Widespread Expression of a Membrane-Tethered Version of the Soluble Lysosomal Enzyme Palmitoyl Protein Thioesterase-1. JIMD reports. 2017.
     

  4. Stanley M, Macauley SL, Caesar EE, Koscal LJ, Moritz W, Robinson GO, Roh J,Keyser J, Jiang H, Holtzman DM. The Effects of Peripheral and Central High Insulin on Brain Insulin Signaling and Amyloid-β in Young and Old APP/PS1 Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2016; 36(46):11704-11715.
     

  5. Stanley M, Macauley SL, Holtzman DM. Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence? The Journal of experimental medicine. 2016; 213(8):1375-85.
     

  6. Macauley SL. Combination Therapies for Lysosomal Storage Diseases: A Complex Answer to a Simple Problem. Pediatric endocrinology reviews : PER. 2016; 13 Suppl1:639-48.
     

  7. Harris RA, Tindale L, Lone A, Singh O, Macauley SL, Stanley M, Holtzman DM, Bartha R, Cumming RC. Aerobic Glycolysis in the Frontal Cortex Correlates with Memory Performance in Wild-Type Mice But Not the APP/PS1 Mouse Model of Cerebral The Journal of neuroscience : the official journal of the Societyfor Neuroscience. 2016; 36(6):1871-8.
     

  8. Macauley SL, Stanley M, Caesar EE, Yamada SA, Raichle ME, Perez R, Mahan TE, Sutphen CL, Holtzman DM. Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo. The Journal of clinical investigation. 2015; 125(6):2463-7.
     

  9. Macauley SL, Holtzman DM. Recent Advances from the Bench Toward the Bedside in Alzheimer’s Disease. EBioMedicine. 2015; 2(2):94-5.
     

  10. Macauley SL, Wong AM, Shyng C, Augner DP, Dearborn JT, Pearse Y, Roberts MS, Fowler SC, Cooper JD, Watterson DM, Sands MS. An anti-neuroinflammatory that targets dysregulated glia enhances the efficacy of CNS-directed gene therapy in murine infantile neuronal ceroid lipofuscinosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014; 34(39):13077-82.
     

  11. Roberts MS*, Macauley SL*, Wong AM, Yilmas D, Hohm S, Cooper JD, Sands MS. Combination small molecule PPT1 mimetic and CNS-directed gene therapy as a treatment for infantile neuronal ceroid lipofuscinosis. Journal of inheritedmetabolic disease. 2012; 35(5):847-57. *Co-first authors
     

  12. Macauley SL, Roberts MS, Wong AM, McSloy F, Reddy AS, Cooper JD, Sands MS. Synergistic effects of central nervous system-directed gene therapy and bone marrow transplantation in the murine model of infantile neuronal ceroid lipofuscinosis. Annals of neurology. 2012; 71(6):797-804. 
     

  13. Macauley SL, Pekny M, Sands MS. The role of attenuated astrocyte activation in infantile neuronal ceroid lipofuscinosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011; 31(43):15575-85.
     

  14. Reddy AS, Kim JH, Hawkins-Salsbury JA, Macauley SL, Tracy ET, Vogler CA, Han X, Song SK, Wozniak DF, Fowler SC, Klein RS, Sands MS. Bone marrow transplantation augments the effect of brain- and spinal cord-directed adeno-associated virus 2/5 gene therapy by altering inflammation in the murine model of globoid-cell leukodystrophy. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011; 31(27):9945-57.
     

  15. Kielar C, Wishart TM, Palmer A, Dihanich S, Wong AM, Macauley SL, Chan CH, Sands MS, Pearce DA, Cooper JD, Gillingwater TH. Molecular correlates of axonal andsynaptic pathology in mouse models of Batten disease. Human molecular genetics. 2009; 18(21):4066-80.
     

  16. Macauley SL, Sands MS. Promising CNS-directed enzyme replacement therapy for lysosomal storage diseases. Experimental neurology. 2009; 218(1).
     

  17. Macauley SL, Wozniak DF, Kielar C, Tan Y, Cooper JD, Sands MS. Cerebellarpathology and motor deficits in the palmitoyl protein thioesterase 1-deficient mouse. Experimental neurology. 2009; 217(1):124-35.
     

  18. Macauley SL*, Sidman RL, Schuchman EH, Taksir T, Stewart GR. Neuropathology of the acid sphingomyelinase knockout mouse model of Niemann-Pick A disease including structure-function studies associated with cerebellar Purkinje cell degeneration. Experimental neurology. 2008; 214(2):181-92. *Corresponding author
     

  19. Kielar C, Maddox L, Bible E, Pontikis CC, Macauley SL, Griffey MA, Wong M, Sands MS, Cooper JD. Successive neuron loss in the thalamus and cortex in a mouse modelof infantile neuronal ceroid lipofuscinosis. Neurobiology of disease. 2007; 25(1):150-62.
     

  20. Lin D, Donsante A, Macauley S, Levy B, Vogler C, Sands MS. Central nervous system-directed AAV2/5-mediated gene therapy synergizes with bone marrow transplantation in the murine model of globoid-cell leukodystrophy. Molecular therapy : the journal of the American Society of Gene Therapy. 2007; 15(1):44-52.
     

  21. Griffey M, Macauley SL, Ogilvie JM, Sands MS. AAV2-mediated ocular gene therapy for infantile neuronal ceroid lipofuscinosis. Molecular therapy : the journal of the American Society of Gene Therapy. 2005; 12(3):413-21.
     

  22. Passini MA, Macauley SL, Huff MR, Taksir TV, Bu J, Wu IH, Piepenhagen PA, Dodge JC, Shihabuddin LS, O’Riordan CR, Schuchman EH, Stewart GR. AAV vector-mediated correction of brain pathology in a mouse model of Niemann-Pick A disease. Molecular therapy : the journal of the American Society of Gene Therapy. 2005; 11(5):754-62.
     

  23. Shihabuddin LS, Numan S, Huff MR, Dodge JC, Clarke J, Macauley SL, Yang W, Taksir TV, Parsons G, Passini MA, Gage FH, Stewart GR. Intracerebral transplantation of adult mouse neural progenitor cells into the Niemann-Pick-A mouse leads to amarked decrease in lysosomal storage pathology. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004; 24(47):10642-51.
     

  24. Sleat DE, Wiseman JA, El-Banna M, Kim KH, Mao Q, Price S, Macauley SL, Sidman RL, Shen MM, Zhao Q, Passini MA, Davidson BL, Stewart GR, Lobel P. A mouse model ofclassical late-infantile neuronal ceroid lipofuscinosis based on targeted disruption of the CLN2 gene results in a loss of tripeptidyl-peptidase I activity and progressive neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004; 24(41):9117-26.
     

  25. Macauley SL, Horsch AD, Oterdoom M, Zheng MH, Stewart GR. The effects of transforming growth factor-beta2 on dopaminergic graft survival. Cell transplantation. 2004; 13(3):245-52.

     

  1. Macauley SL, Bauer AQ, Moritz W, Caesar EE, Sasaki Y, Mahan TE, and Holtzman DM.  Chronic treatment with the sulfonylurea, glyburide, decreases Alzheimer’s disease pathology by altering neurovascular coupling, neuronal activity, CNS metabolism, and amyloid-β production.  Society for Neuroscience, Washington, DC, 2017.
     

  2. Macauley SL, Caesar EE, Stanley M, Mortiz WR, Mahan TE, and Holtzman DE.  Chronic treatment with sulfonylurea, glyburide, reduces amyloid-beta pathology in the APPswe/PSEN1dE9 mouse model of Alzheimer’s disease.  American Diabetes Association Meeting, June 2016, New Orleans, LA.
     

  3. Macauley SL, Stanley M, Caesar EE, Yamada SA, Raichle ME, Perez R, Mahan TE, and Holtzman DM.  Hyperglycemia modulates extracellular amyloid-beta levels and neuronal activity in vivo.  AD/PD, Nice, France, 2015.
     

  4. Macauley SL, Yamada SA, Stanley M, Perez R, Mahan TE, and Holtzman DM.  The effects of systemic hyperglycemia on amyloid-beta levels within brain interstitial fluid.  Keystone Conference, Keystone, CO, 2014.

Select Meeting Abstracts

The Macauley Lab | Wake Forest School of Medicine

575 N. Patterson Avenue | Winston-Salem, NC 27101

smacaule@wakehealth.edu 336.716.4628

macauleylab.com | @macauleylab