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winnie

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cubs game

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first day

first day

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The Lab!

The Lab!

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Caitlin and EEGs

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Biosensors

Biosensors

Morgan and brains!

Morgan and brains!

ABOUT

As part of the University of Kentucky, the Macauley Lab focuses on the role of metabolic dysfunction in Alzheimer's disease. According to the Alzheimer’s Association, 1 in 8 Americans over the age of 65 has Alzheimer’s disease, nearly 1 in 2 has AD by the age of 85, and AD accounted for an estimated $183 billion in health care costs to Americans in 2011. Similarly, type-2-diabetes is metabolic disorder that affects approximately 346 million people worldwide, with an estimated 3.4 million dying from diabetes in 2004 alone. Since recent studies demonstrate that patients with type-2-diabetes have an increased risk for developing AD, the goal of our research is to understand how metabolic disruption affects Alzheimer's disease and whether shared mechanisms between type-2-diabetes and Alzheimer's disease can be targeted therapeutically.

LAB MEMBERS

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Shannon L. Macauley, PhD

Principal Investigator

Dr. Macauley's CV        

Associate Professor, Dept of Physiology, University of Kentucky

Adjunct Associate Professor, Dept of Physiology & Pharmacology, Wake Forest School of Med

Education/Training: BA, Middlebury College; PhD, Washington University School of Medicine; Postdoctoral Fellowship, Washington University School of Medicine
 

Shannon L. Macauley earned her BA in Biology and Psychology from Middlebury College (Middlebury, VT) and worked in translational neuroscience at Genzyme Corporation (Boston, MA) prior to graduate school.  Dr. Macauley completed her Ph.D. in Neuroscience at Washington University (St. Louis, MO) with Dr. Mark Sands and her postdoctoral training in Alzheimer’s disease in the laboratory of Dr. David Holtzman at Washington University (St. Louis, MO).  Dr. Macauley joined the Sticht Center for Healthy Aging and Alzheimer’s Prevention at Wake Forest Baptist Health as an Assistant Professor in August 2017. Dr. Macauley was promoted to Associate Professor with Tenure in 2022. She recently moved her lab to University of Kentucky in June of 2023.

 

The goal of Dr. Macauley’s research is to understand central nervous system (CNS) disease and how mechanistic drivers of neuronal dysfunction, such as metabolic dysfunction, sleep impairment, vascular damage, and neuroinflammation, can be targeted therapeutically,  To date, her work has focused on two main areas: first, the study of mechanisms underlying neurodegenerative disease and the development of CNS therapeutics as it relates to lysosomal storage diseases.  Second, the exploration of the link between type 2 diabetes and Alzheimer’s disease, how metabolic challenges affect normal brain function in health and disease, and how metabolic dysfunction can be targeted as a therapeutic approach for treatment of Alzheimer’s disease and diabetes.

Current Members  

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Andy
Snipes
Nick
Constantino
Riley
Irmen, MS

Research Assistant/

Lab Manager Extraordinaire

3rd year PhD student

Neuroscience

2nd year PhD student

Physiology

Past Members  

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Stephen
Gironda, MS
Stephen
Day, PhD
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Caitlin
Carroll, PhD

3rd year PhD student

Neuroscience

F31 Fellow

Postdoctoral Fellow

T32 fellow

Current: Research Track,

Assistant Prof, SUNY Binghamtom

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Dave
Rubinow, MS
Khadijah
Winkey Lewis, MS

Masters Student

Neuroscience

Current: Clinical Coordinator ADRC

Masters Student

Neuroscience

Current: Kallyope Inc.

Neuroscience PhD Student

F31 awardee

Current:  T32 PostDoc

with Dr. Ruth Benca, Wake Forest

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Sami
Vincent

Wake Forest, Honors Thesis

Current: Masters in Bioethics &

Wake Forest Law Student

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Morgan
Pait, PhD

IPP PhD Student

F31 Awardee

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Zhen
Lin, MS

2nd year PhD student

BME

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Matthew
Parker
John
Grizzanti, PhD

WSSU, ENGAGED Scholar

Current: Master's Student

Postdoctoral Fellow

T32 fellow

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Ryan
Pettit-Mee, MS, PhD
Lily
Deitelzweig

High School Student intern
Current: Undergrad UT-Austin

Postdoctoral Fellow

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Charlotte Hollingsworth

Lab Manager

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